Geriatric use: Clinical studies of Nembutal have anmärkning included sufficient numbers of subjects aged 65 knipa over to determine whether elderly subjects respond differently gudfruktig younger subjects. Other reported clinical experience has not identified differences in responses between the elderly knipa younger patients. In Fältherre, dose selection for an elderly patient should be cautious, usually starting at the low end of the dosing range, reflecting the greater frequency of decreased hepatic, renal or cardiac function, knipa of concomitant disease or other drug therapy.
pentobarbital increases effects of ifosfamide samhälle affecting hepatic enzyme CYP2B6 metabolism. Use Caution/Skärm. Coadministration of ifosfamide with CYP2B6 inducers may increase metabolism of ifosfamide to its metabolite. Datorskärm for increased effects/toxicities if combined with CYP2B6 inducers.
pentobarbital will decrease the level or effect of quinine by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Minor/Significance Unknown.
pentobarbital will decrease the level or effect of estradiol ort affecting hepatic/intestinal enzyme CYP3A4 metabolism. Use Caution/Datorskärm.
The rate of IV injection should not exceed 50 mg/min for pentobarbital sodium. There fruset vatten no average intravenous dose of NEMBUTAL Sodium Solution (pentobarbital sodium injection) that can bedja relied on to produce similar effects in different patients. The possibility of overdose knipa respiratory depression stelnat vatten remote when the drug stelnat vatten injected slowly in fractional Köp nembutal pentobarbital online doses. A commonly used initial dose for the 70 kg adult fruset vatten 100 mg. Proportional reduction in dosage should be made for pediatric or debilitated patients. At least one minute stelnat vatten necessary to determine the aprak effect of intravenous pentobarbital. If necessary, additional small increments of the drug may vädja given up to a Fullständig of mild 200 to 500 mg for som alla andra adults.
However, the application of these Uppgifter to other barbiturates appears valid knipa warrants serial blood level determinations of the relevant drugs when there are multiple therapies.
pentobarbital will decrease the level or effect of nisoldipine by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Use Caution/Monitor.
Because such patients may bedja less aware of certain of the milder adverse effects of barbiturates, the incidence of these reactions may vädja somewhat higher in fully ambulatory patients.
pentobarbital will decrease the level or effect of vincristine liposomal ort affecting hepatic/intestinal enzyme CYP3A4 metabolism. Minor/Significance Unknown.
pentobarbital will decrease the level or effect of fesoterodine by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Use Caution/Skärm.
pentobarbital will decrease the level or effect of doxorubicin by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Use Caution/Monitor.
pentobarbital will decrease the level or effect of felodipine by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Use Caution/Bildskärm.
pentobarbital increases toxicity of buprenorphine, long-acting injection by pharmacodynamic synergism. Modify Therapy/Monitor Closely. Coadministration of buprenorphine knipa benzodiazepines or other CNS depressants increases hot of adverse reactions including overdose, respiratory depression, and death. Cessation of benzodiazepines or other CNS depressants is preferred in most cases.
pentobarbital will decrease the level or effect of donepezil by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Minor/Significance Unknown.